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Gene mutation helped the blockade of Leningrad survive - VIDEO PDF Print E-mail
Wednesday, 10 June 2015 03:00

Russian geneticists compared the device of some genes in the DNA of ordinary Russians and the blockade of Leningrad, and found unusual mutations in the genes of UCP and PPAR, which helped them to survive in conditions of severe hunger and stress, writes edition of the journal Science.

The Siege of Leningrad is one of the most tragic events of the Great Patriotic War. German troops approached the city in early September 1941, and lifted the siege only in January 1944. Over the years, the blockade killed more than 1.5 million people, the vast majority of residents - 97% - have died from hunger and disease.

Winter 1941, as noted in all the chronicles of the siege was the most difficult period for the defenders. At that time, residents received an average of 200 calories per day, with a noticeable part of this "diet" come to malosedobnye things - pine bark, birch buds and flaxseed bread. In such circumstances, even the slightest variations in the digestive system and metabolism affect the survival of the person.

Oleg Glotov from the Institute of Obstetrics and Gynecology named Ott in St. Petersburg and several other Russian geneticists decided to find out which variation in the genes and the whole body can help survivors of the blockade to transfer all these hardships.

To do this, researchers gathered a group of two hundred residents of Leningrad survivors siege of the city, they took their blood samples and DNA. They analyzed the structure of the genes that are responsible for metabolism and cell function in a lack of food, and compared them with those parts of the genome of the Russians, whose ancestors were victims of Nazi brutality.

As it turned out, the structure of the three genes involved in metabolism - two genes of PPAR family and one gene from the group UCP - DNA blockade was significantly different compared to people in the control group. According Glotov and his colleagues, their versions of these genes contained a specific mutation that increases the efficiency of the mitochondria, the cell power plants and reduces energy losses to heat the body.

The study of these genes is not only useful for assessing how our DNA influences the device on human survival, but also to develop ways to combat obesity, anorexia and other metabolic disorders.


НАЖМИТЕ ЗДЕСЬ ДЛЯ ПРОСМОТРА ВСЕГО СПИСКА НОВОСТЕЙ О НЕОБЫЧНЫХ ЯВЛЕНИЯХ>>>

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