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Created a vaccination against diabetes - VIDEO PDF Print E-mail
Saturday, 24 January 2015 12:05

Successful experiments on mice gave hope to create an effective prevention of diabetes of the first type, which affects millions of young people around the world. New drug stops the destruction of beta cells that produce insulin.
Scientists from the University of St. Louis have found a way to prevent type I diabetes in mice by blocking autoimmune processes responsible for the destruction of pancreatic beta cells. Perhaps based on this technology will be able to create effective ways to prevent and treat one of the most common and dangerous diseases.

  Diabetes - a chronic autoimmune disease in which the immune system of the organism "in error" destroys the insulin-producing beta cells. As a result, diabetes can lead to hormone deficiency and hyperglycemia - increased content of glucose in the blood. In contrast, type II diabetes, type I diabetes does not develop in old age, and occurs mainly in young people and even children. Unfortunately, the treatment of this disease does not exist yet, and patients have a lifetime to control blood sugar levels and take insulin.

But even so, diabetes is associated with a variety of life-threatening complications such as the risk of death from cardiovascular diseases in patients with diabetes is several times higher than in healthy people. In total there are about 250 million people with diabetes in Russia - more than 2.5 million. Experts say the global increase in the number of cases, the number of people with high blood glucose levels that are not asked for help, it may be several times higher.


For many people, the only way to save a life with type I diabetes - a regular intake of insulin

A new study led by Dr. Thomas Barris (Thomas Burris) and published in the publication of Endocrinology, offers a new way of preventing diabetes, not just treat its symptoms. According to Thomas Burris, a new kind of treatment may slow the development of type I diabetes, or even eliminate the need for insulin injections.

So far scientists have known that at least two types of immune T-cells are responsible for the development of type I diabetes. The role of the third type of cells (TH17) was unclear. Burris Thomas and colleagues found that a pair of nuclear receptors play an important role in the development of Th17-cells. Moreover, they can stop the autoimmune disease in several mouse models, retaining their beta cells from destruction.


Scientists have developed a special substance that blocks the receptors ROR alpha and gamma t antagonist called SR1001. This material greatly reduces manifestations of diabetes in mice and may be used to prevent the destruction of insulin-producing beta cells.

These data show that Th17 cells play an important role in the development of type I diabetes. Researchers believe very promising drugs that act on these cells. Such drugs will help suppress diabetes in the very early stages of development and prevent any dangerous for health and life-threatening complications. Globally, the new drug could save millions of lives and save billions of dollars that are now being spent on ineffective insulin therapy and treatment of associated symptoms.


НАЖМИТЕ ЗДЕСЬ ДЛЯ ПРОСМОТРА ВСЕГО СПИСКА НОВОСТЕЙ О НЕОБЫЧНЫХ ЯВЛЕНИЯХ>>>

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