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Ibuprofen prolongs life - VIDEO PDF Print E-mail
Saturday, 20 December 2014 10:30

American and Russian scientists have discovered a property of the drug ibuprofen prolong life. This was reported by the authors of an article in the journal PLoS genetics.

Ibuprofen general refers to a group of non-steroidal anti-inflammatory drugs. The main active ingredient of the agent created based on propionic acid.

The drug was created in 1960 in the UK, where he first became available by prescription. Already in the 1980s means globally deployed. The tool has analgesic and antipyretic activity and is included in the list of essential medicines WHO.

In their study, the researchers showed that ibuprofen increases the lifespan of baker's yeast (Saccharomyces cerevisiae), free-living nematodes (Caenorhabditis elegans), and black-fruit flies (Drosophila melanogaster).

Organisms after administration of ibuprofen to 15 percent lived longer. Additionally, they were more healthy compared to organisms that do not have access to the drug. According to the experts, based on the person it could mean an increase in the lifetime of a term of ten years.

Studies in yeast demonstrated that ibuprofen and destabilizes Tat2p inhibits permease (slow) uptake of tryptophan and other aromatic acids. Tat2p loss increases replicative life span (the number of times a cell can divide).

Simultaneously with the increase in life expectancy ibuprofen significantly reduce the average size of the cells at its birth. This leads to delays in G1-phase of the cell cycle. It is at this stage of the cell cycle are synthesized mRNA and proteins required for DNA synthesis and it becomes clear whether the cell to divide or go into a state of rest (G0-phase).

"Buck Institute is interested in the study of the reasons why people get sick in the aging process. We believe that by understanding this, we can step in and find ways to preserve human health and slow aging. It is our ultimate goal, "- said Brian Kennedy, head of the Institute, who led the study.

In the work involved and Russian biologists affiliation with the Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences, Syktyvkar State University and the Moscow Physical-Technical University.

On the American side involved experts from the Institute of Baka in the Californian city of Novato Texas, as well as from the Texas A & M University and the University of Washington in Seattle.

About a year ago, scientists discovered and anti-cancer properties of the drug. In the new study, as the authors note, they found a rejuvenating effect of ibuprofen, regardless of its anti-inflammatory role.

According to geneticists, given the wide dissemination and consideration of the drug remains an interesting question for further study of drug action, particularly in the context of identifying properties of the cell cycle associated with longevity.


НАЖМИТЕ ЗДЕСЬ ДЛЯ ПРОСМОТРА ВСЕГО СПИСКА НОВОСТЕЙ О НЕОБЫЧНЫХ ЯВЛЕНИЯХ>>>

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